dose-response curve with variable hill slope-function Search Results


standard slope dose response function with plateaus  (GraphPad Software Inc)
90
GraphPad Software Inc standard slope dose response function with plateaus
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Standard Slope Dose Response Function With Plateaus, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dose–response functions  (GraphPad Software Inc)
90
GraphPad Software Inc dose–response functions
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Dose–Response Functions, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sigmoidal dose-response (variable slope) function  (GraphPad Software Inc)
90
GraphPad Software Inc sigmoidal dose-response (variable slope) function
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Sigmoidal Dose Response (Variable Slope) Function, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prism 4.0c  (GraphPad Software Inc)
90
GraphPad Software Inc prism 4.0c
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Prism 4.0c, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prism 4.0c - by Bioz Stars, 2026-03
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sigmoid dose-response (variable slope) function  (GraphPad Software Inc)
90
GraphPad Software Inc sigmoid dose-response (variable slope) function
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Sigmoid Dose Response (Variable Slope) Function, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prism sigmoidal dose-response (variable slope) function  (GraphPad Software Inc)
90
GraphPad Software Inc prism sigmoidal dose-response (variable slope) function
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Prism Sigmoidal Dose Response (Variable Slope) Function, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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curve-fitting function (sigmoidal dose response, variable slope) of graph pad prism version 4.03 for windows  (GraphPad Software Inc)
90
GraphPad Software Inc curve-fitting function (sigmoidal dose response, variable slope) of graph pad prism version 4.03 for windows
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Curve Fitting Function (Sigmoidal Dose Response, Variable Slope) Of Graph Pad Prism Version 4.03 For Windows, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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log(dose)-response curve variable slope normalized function  (GraphPad Software Inc)
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GraphPad Software Inc log(dose)-response curve variable slope normalized function
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Log(Dose) Response Curve Variable Slope Normalized Function, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nonlinear regression–curve fit (sigmoidal dose response with variable slope) function  (GraphPad Software Inc)
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GraphPad Software Inc nonlinear regression–curve fit (sigmoidal dose response with variable slope) function
Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) <t>Dose</t> <t>response</t> with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a <t>standard</t> <t>slope</t> dose response <t>function</t> with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.
Nonlinear Regression–Curve Fit (Sigmoidal Dose Response With Variable Slope) Function, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) Dose response with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a standard slope dose response function with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.

Journal: Scientific Reports

Article Title: Conservation of Cdc14 phosphatase specificity in plant fungal pathogens: implications for antifungal development

doi: 10.1038/s41598-020-68921-3

Figure Lengend Snippet: Fungal Cdc14 homologs can be specifically inhibited by a substrate mimetic. ( a ) Structure of the synthetic peptide used for inhibition assays (sequence Glu-Val-pCF 2 Ser-Pro-Thr-Lys-Arg-amide). ( b ) Dose response with the pCF 2 Ser peptide from A and the indicated fungal Cdc14 enzymes using DiFMUP as substrate. Data represent the average of 5 or 6 independent trials. It was not practical to show error bars on the graph, however error values for replicate K i measurements are provided in ( c ). Best fit lines were generated with a standard slope dose response function with plateaus set at 100% and 0% in Graphpad Prism. We did not have enough pCF 2 Ser peptide to perform the full analysis on all 8 plant fungal pathogen homologs. ( c ) Each individual trial from the experiment in ( b ) was fit as described in b to generate IC 50 , from which K i was calculated (see “ ”). Values represent the mean ± standard deviation. ( d ) Comparison of pCF 2 Ser peptide inhibition of human tyrosine phosphatase PTP1B and dual specificity phosphatase VHR to ScCdc14 and human Cdc14A using DiFMUP at the measured K M for each enzyme. Percent activity relative to a no inhibitor control was calculated and plotted. Data are means of 3 independent experiments and error bars are standard deviations. Numbers over the bars are p values from a t- test (unpaired, one-tail) comparing 0 and 200 µM inhibitor data.

Article Snippet: Best fit lines were generated with a standard slope dose response function with plateaus set at 100% and 0% in Graphpad Prism.

Techniques: Inhibition, Sequencing, Generated, Standard Deviation, Comparison, Activity Assay, Control